FOXO3 and metabolic bone disorder: The top 60 DE lncRNA-targeted mRNAs are shown in Supplementary Table 1, including forkhead box O3 (FOXO3), signal-regulatory protein beta 1 (SIRPB1), interleukin 1 receptor type I (IL1R1), etc. FOXO3 has been reported to be important in the control of ROS levels in bone metabolic disorders via the activation of autophagy (Wang et al., 2020), while another member of the FOXO family, FOXO1, has been indicated in SAPHO syndrome (Berthelot et al., 2018).