ACAA1 and metabolic disease: ACAA1 is an important regulatory gene involved in cell lipid metabolism (Wanders et al., 2001) and is a target of biotherapy for human metabolic diseases (Colas et al., 2011; Park et al., 2012; Klimosch et al., 2013; Liu et al., 2015; Nwosu et al., 2018; Zhang et al., 2019).