However, high titers of virus-binding and neutralizing antibody in combination with a CD4+ T helper type 1 response and a solid amount of SARS-CoV-2-specific cytotoxic CD8+ T cells seem to be suitable predictors of a reduced risk of infection with SARS-CoV-2 and of a decreased probability of severe COVID-19 disease (11, 12). The gene discussed is CD8A; the disease is infection.