CD4 and acute kidney injury: To address this in AKI/AKD, our flow cytometric analysis showed that the number of kidney CD4−CD8+ T cells was selectively reduced in Irf8-deficient mice overtime after IRI (Figures 6F, H), without differences in the numbers of infiltrating kidney CD4−CD8−, CD4+CD8+, and CD4+CD8− T cells after IRI.