Specifically, because the IL-10-STAT3 axis inhibits ~20% of LPS-induced genes (1), failure of IL-10 to inhibit cytokine production from IL-10 resistant monocytes/macrophages during endotoxemia may explain why various pro-inflammatory cytokines are elevated despite high IL-10 levels in severe COVID-19 cases. The gene discussed is IL10; the disease is COVID-19.