Mechanistically, the hyporesponsiveness to IL-10 action correlated with impaired STAT3 phosphorylation under hyperglycemia and responsiveness was restored with a small molecule activator of the inositol phosphatase SHIP1 (12), highlighting the STAT3/SHIP1 axis as a potential target for restoring IL-10 action (4). This evidence concerns the gene STAT3 and Hyperglycemia.