Accordingly, antibody mediated T cell depletion, and especially cytotoxic CD8+ T cell depletion, compromises immune control of EBV infection in mice with reconstituted human immune system components (Strowig et al., 2009; Yajima et al., 2009; Chijioke et al., 2015; Murer et al., 2019; McHugh et al., 2020). The gene discussed is CD8A; the disease is Epstein-Barr virus infection.