Hypercoagulation status was identified in several cases, including five (21.7%) with Protein S deficiency, six (26.1%) with Protein C deficiency, five (21.7%) with antithrombin III (AT-III) deficiency, and two (8.9%) with hyperfibrinogenemia. The gene discussed is SERPINC1; the disease is hyperinsulinemic hypoglycemia, familial, 4.