NFKB1 and Hyperglycemia: NF-κB pathway is the central converging point of inflammatory triggers stemming from several pathological stresses in diabetes, such as prolonged endoplasmic reticulum stress, hyperlipidemia, hyperglycemia, renin–angiotensin–aldosterone system (RAAS) activation (Knapp et al., 2019), oxidative stress (Maier et al., 2012), and advanced glycation end products (AGEs) (Palomer et al., 2013).