Probiotics, fungi, and medicinal plants exert an anti-inflammatory action via downregulation of TLR4 expression (Chiang et al., 2021) and reduction of IL-1β, TNFα, MCP-1, and TGFβ (Wang et al., 2018; Shaher et al., 2020), subsequently preserving cardiac structure and function in T1DM rodents. This evidence concerns the gene TLR4 and type 1 diabetes mellitus.