In C57BL/6J mice, induction of type1 (T1D) diabetes by administration of streptozotocin (STZ) was associated with increased LC3-II immunoreactivity in the outer plexiform layer (OPL) and upregulation of the Atg related proteins, Beclin-1 and Atg5 (Piano et al., 2016). The gene discussed is BECN1; the disease is type 1 diabetes mellitus.