IGF1 and Cognitive impairment: Considering all the evidence aforementioned, and the fact that IGF-1 gene therapy targets brain cells in vivoHereñú et al. (2009) and can decrease behavioral functional impairments in aged rats (Nishida et al., 2011; Pardo et al., 2017), the aim of the present study is to evaluate the effectiveness of early IGF-1 gene therapy in the treatment of TBI for preventing OS as well as improving cognitive deficits.