Considering that the NLRP3 inflammasome plays an important role in the Treg/Th17 cell balance, which in turn regulates autoimmunity, we speculated that YH treatment alleviated autoimmune thyroiditis in rats, which could be due to the Th17/Treg rebalancing regulated by Wnt/β-catenin pathway through NLRP3 inflammasome deactivation (Figure 11). The gene discussed is NLRP3; the disease is Autoimmunity.