Infection of neurons by JEV, RV, and HSV-1 increases activation of ERK1/2 and PKC (Park and Baines, 2006; Yang et al., 2010; Ye et al., 2013; Manjunatha et al., 2017), kinases with an established role in the activation of CDyn-based retrograde FAT (Morfini et al., 2007; Mitchell et al., 2012). Here, MAPK3 is linked to infection.