SLC1A1 and Anxiety: In EAAT3 knockout (KO) mice, early studies found no alterations in anxiety or compulsive-like behaviors at 6–8 weeks old but reported a reduction in self-grooming behavior at 10–12 months old (Aoyama et al., 2006), while a recent study found increased grooming in EAAT3 KO mice at an early age, from postnatal day 14 to 35 (Bellini et al., 2018).