TMEV-DA-induced lesions mimic features of MS cortical lesions in that chronic demyelinating white matter has extensive peripheral leukocyte infiltrates, the majority of which are CD4+ (Palma et al., 1999; Mohindru et al., 2006) and CD8+ T cells (Begolka et al., 2001; Lyman et al., 2004), though some monocytes/macrophages (Mack et al., 2003) and comparably few B cells are also present (Gilli et al., 2015). This evidence concerns the gene CD4 and myeloid sarcoma.