IFNG and myeloid sarcoma: Notably, IFNγ has been heavily implicated in MS pathology, as it is known to promote Th1 responses (Olsson, 1992; Fletcher et al., 2010), but it may also impact neurons directly by enhancing glutamate toxicity through dysregulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic (AMPA) receptors, which results in calcium influx, nitric oxide (NO) production, and a decrease in mitochondrial function (Mizuno et al., 2008).