Feneberg et al. (2018) investigated the diagnostic performance of CSF NFL for ALS patients who are evaluated early in the disease course, i.e., within 6 months from symptom onset: also these patients had higher CSF NFL levels than the other categories, including MND mimics, resulting in good discrimination of ALS from MND mimics with AUC 0.94, sensitivity 89%, and specificity 94%. Here, NEFL is linked to amyotrophic lateral sclerosis.