TARDBP and amyotrophic lateral sclerosis: The large majority of ALS cases occur sporadically, but 5–10% of ALS patients have a family history, usually with autosomal dominant inheritance, and approximately two thirds of them harbor mutations in one (or sometimes more) of > 20 genes, the most common being the (G4C2)n hexanucleotide repeat expansion (HRE) in the C9orf72 gene and mutations in the genes SOD1, TARDBP, and FUS (Mejzini et al., 2019).