NEFL and frontotemporal dementia: In the large investigation of van der Ende et al. (2019) on serum NFL in carriers of FTD gene mutations, negative correlations were observed at baseline between NFL and mostly frontotemporal brain volumes; moreover, in the whole cohort, the rate of change of serum NFL over time was associated with the longitudinal change in the volume of the whole brain and in the volumes of the frontal lobe, insula, cingulate gyrus, hippocampus, putamen, temporal lobe, amygdala, and cerebellum.