Bhati et al. (2019), in their recent study, confirmed the relationship between biomarkers of inflammation to the measures of cardiac vagal tone and HRV, linking the subclinical inflammation to CAN presentation. von Känel et al. (2008), with his study team, described a significant association between systemic low-grade inflammatory activity and decrease in HRV in healthy subjects, confirming a positive relationship between plasma levels of interleukin (IL)-6 and soluble tissue factor (sTF), when HRV was low4. The gene discussed is F3; the disease is Crouzon syndrome-acanthosis nigricans syndrome.