MAPT and Alzheimer disease: Diseases involving tau protein misfolding or hyperphosphorylation and accumulation are known as tauopathies; these include AD, frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), Pick’s disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and chronic traumatic encephalopathy (Villemagne et al., 2015; Okamura et al., 2018).