This Cn/NFAT signature in T-ALL differs from the NFAT-dependent signature characteristic of the TCR-dependent activation of peripheral T cells as no difference in expression in e.g. the genes encoding IL2, IL3, IL4, IL5, IL13, IFNg, GM-CSF was found upon CnB1 or Nfat deletion in T-ALL cells. This evidence concerns the gene IL3 and acute lymphoblastic leukemia.