PPP3R1 and acute lymphoblastic leukemia: As expected, expression of exogenous CnB1 restored the ability of T-ALL cells to survive and proliferate (Fig 4C, left panel, blue tracing) concomitant with the rapid amplification of GFP+ cells (Fig 4C, right panel, blue tracing) that retain the parental CnBdel/del genotype (Fig 4D).