IRF1 and acute lymphoblastic leukemia: However, expression of neither pro-inflammatory cytokines (TNFa, IL-10, IL-16, IL32, 34, CSF-1, CCL6, 9, CXCL9, 10) nor IFN-response genes (IRF1, 2, 7, 8, 9) identified as down-regulated in STIM1/2-deficient T-ALL [28] were found modulated in NFAT-deficient cells.