NFATC1 and acute lymphoblastic leukemia: Leukemic cells recovered from terminally-leukemic recipients injected with RCT2; Nfat1-/-; Nfat2+/+; Nfat4del/del T-ALL kept their original Nfat genotypes (Fig 3B; right panels), showing that LIC activity was effectively driven by NFAT2.