Of note, T-ALL cells recovered from terminally leukemic recipient mice injected with RCT2; Nfat1-/-; Nfat2del/del; Nfat4+/+ T-ALL cells kept their original Nfat genotypes (Fig 3B, left, “recovered” panel), indicating that the mere expression of NFAT4 is sufficient to maintain the leukemia initiating potential of T-ALL. Here, NFATC3 is linked to acute lymphoblastic leukemia.