To this end, we generated ICN1-driven tumors in which only Nfat4 (ICN1; RCT2; Nfat1-/-; Nfat2fl/fl; Nfat4+/+) or only Nfat2 (ICN1; RCT2; Nfat1-/-; Nfat2+/+; Nfat4fl/fl) will remain expressed following genetic inactivation of the other family members following Tam treatment and analyzed the leukemia initiating potential of these cells (See Fig 3A for a scheme of the experiment). The gene discussed is NFATC2; the disease is leukemia.