ACE and diabetes mellitus: Results from the present meta-analysis showed that ARBs had no significant difference on QUICKI score, FPG, FPI, SBP, and DBP compared with ACE inhibitors; however, ACE inhibitors resulted in more effective improvement of HOMA-IR compared with ARBs among the long-term intervention subgroup and hypertensive patients with DM subgroup; furthermore, the efficacy of ACE inhibitors on improving GIR and ISI composite was significantly better than that of ARBs in hypertensive patients or hypertensive postmenopausal women.