IDH1 and glioblastoma: The well-known mutations identified in glioblastoma have subsequently lead to the identification of epigenetic and transcriptomic mechanisms which perpetuate the disease: examples of this are the hypermethylation of CpG islands in IDH1-mutant glioblastoma [4] and the loss of histone H3.3 K27me3 in H3.3 mutant glioblastomas [5].