In glioblastomas only three PFKFB3 transcripts -1, -4 and -11 (former UBI2K4, 5 and 6) were detected, with decreased mRNA levels documented for PFKFB3-4 [20, 21], compared to low-grade astrocytomas and normal brain tissue. This evidence concerns the gene PFKFB3 and astrocytoma (excluding glioblastoma).