The discrepancy between the growth inhibiting effects induced by PFKFB3-4+5 knockdown, as well as the overexpression of the PFKFB3-4 fusion protein requires a more detailed investigation of PFKFB3-4 in the glioblastoma context, especially with regard to the putative effects of biochemical tag fusion [29]. The gene discussed is PFKFB3; the disease is glioblastoma.