To determine the involvement of PIAS2 in sPD, WT, Ifnb–/–, and Ifnar1–/– mice were injected with AAVs vectors that overexpress PIAS2-mCherry or mCherry-only under the neuron-specific SYN1 promoter in the SN and frontal cortex of the brain. The gene discussed is IFNB1; the disease is Platelet storage pool disease.