Thus, we studied the enrichment of functionally related genes downstream of IFNAR: IFNAR1, STAT1, STAT2, JAK1, JAK2, AKT1, TYK2, SOCS1, SOCS3, and PIAS2. We identified 43 nominally significant sequence variants in PIAS2, JAK2, TYK2, and AKT1 (Table 1) that were associated with sPD patients. Here, JAK2 is linked to Platelet storage pool disease.