TYK2 and Platelet storage pool disease: Thus, we studied the enrichment of functionally related genes downstream of IFNAR: IFNAR1, STAT1, STAT2, JAK1, JAK2, AKT1, TYK2, SOCS1, SOCS3, and PIAS2. We identified 43 nominally significant sequence variants in PIAS2, JAK2, TYK2, and AKT1 (Table 1) that were associated with sPD patients.