Interestingly, we demonstrated that PI3K/AKT signaling pathway, EGFR tyrosine kinase inhibitor resistance, non-small cell lung cancer and osteoclast differentiation were associated with ALK-positive lung cancer (Fig. 3A), all KEGG terms are statically significant (adjusted P value < 0.05). Here, AKT1 is linked to non-small cell lung carcinoma.