Then, we further analyzed mRNA expression of TP53 in the same five ALK-positive lung cancer samples and the corresponding pericarcinous (normal) tissues by NanoString assay, and we found mRNA overexpression of TP53 in the ALK/TP53 co-mutated lung cancer sample (case 4) compared to the corresponding pericarcinous tissues (45-fold). The gene discussed is TP53; the disease is lung cancer.