NFKB1 and nasopharyngeal carcinoma: Firstly, our results show that constitutive activation of the NF-κB inflammatory pathways occurs in as high as 90% of NPC either through somatic alterations or expression of the virus-encoded LMP1 oncogene, implicating aberrant NF-κB activation as a ubiquitous hallmark of this EBV-associated malignancy.