While the heterozygous loss of chr 3p is a known feature of NPC (64/70, 91.4% in our cohort), we also discovered recurrent homozygous deletions and SVs of TGFBR2 at 3p24.1 in 11.4% of our tumors (Fig. 2). This evidence concerns the gene TGFBR2 and nasopharyngeal carcinoma.