CYLD and cancer: In addition, recurrent breakpoints of SVs targeting cancer genes commonly occurred in frequently deleted regions, e.g., CDKN2A on 9p21.3, MAML2 and ATM on 11q21-22, RAD51B, and TRAF3 on 14q 24-32.3, CYLD and NLRC5 on 16q12.1-13 (Fig. 2).