Importantly, using microdissected tumor samples and WGS, we detected the highest frequencies of homozygous deletions of the critical tumor suppressor genes CDKN2A, TGFBR2, TRAF3, and potential synthetic lethal target MTAP amongst NPC genomic reports thus far8–14. The gene discussed is TGFBR2; the disease is nasopharyngeal carcinoma.