Finally, immunohistochemistry (IHC) staining showed that the protein expressions of both MYBL2 and RRM2 were significantly upregulated in the cancer tissues compared to their paired normal tissues in our cohort of 69 CRC patients (Figs. 1H, 1I) with a strong correlation coefficient between their expression levels (Fig. 1J). Here, MYBL2 is linked to colorectal carcinoma.