Furthermore, SIN3A mediates STAT3 transcriptional repressor activity24 and along with genes involved in histone modification such as HDAC and Lysine specific demethylase (LSD), inhibits several cancer genes including CASP7, TGFB2, CDKN1A, HIF1A, TERT and MDM225. This evidence concerns the gene CDKN1A and cancer.