The potential roles of NLRP3 inflammasome in severe COVID-19 have been discussed in relevant reviews.164,165 Reactive oxygen species (ROS) was reportedly an initiator of NLRP3 activation.166–168 Thus, it was proposed that excessive production of ROS resulting from inflammation infiltration in severe COVID-19 may lead to NLRP3 activation and IL-1β precursor cleavage, further aggravating inflammation in COVID-CS. This evidence concerns the gene IL1B and COVID-19.