IL1B and Cowden syndrome 1: The current treatment for CS is mainly based on traditional anti-inflammatory drugs such as the administration of corticosteroids, chloroquine, and colchicines.210,211 Recently, biologics like recombinant cytokines; monoclonal antibodies against IL-6, IL-1β, TNF-α, and IFN-γ; and signaling pathway inhibitors are also available or in the pipeline for production.