CDK7 and congenital rubella syndrome: CDK7 can regulate cell cycle and gene transcription.378 Previous studies have shown that blockade of CDK7 manipulated inflammation resolution by remodeling antitumor immunity378 and regulating cytokine secretion.379 A recent study by Wei et al.380 showed that small-molecule inhibitor, THZ1, mediated the blockade of CDK7 and thus mitigated hyperinflammatory states and CRS caused by CAR T cell therapy.