Considering the supportive roles of IL-2 in the expansion and differentiation of T cells, the authors speculated that the presence of lymphopenia especially in severe COVID-19 may be attributed to reduced levels of IL-2, IL-2R, JAK1, and STAT5.175 In additionally, CD4+ T cells are the primary source of IL-2, and the reduced numbers of lymphocytes during the stage of CS after COVID-19 infection can at least partly explain the reduced IL-2 level and downregulation of IL-2 signaling. This evidence concerns the gene IL2 and Cowden syndrome 1.