CD14 and COVID-19: Interestingly, a two-cohort study showed that activated HLA-DRhighCD11chighCD14+ monocytes were increased in the PBMCs of patients with mild COVID-19, whereas dysfunctional HLA-DRlowCD163high (indicative of anti-inflammatory function) CD14+ monocytes were observed in severe COVID-19 cases.59 This merits further investigation to understand the underlying mechanism and clinical significance.