A retrospective, multicenter study including 150 patients from Wuhan, China showed significantly elevated levels of IL-6 in severe COVID-19 cases.103 A study from Germany showed that IL-6 >80 pg/mL in combination with CRP >97 mg/L presented a relatively high specificity and sensitivity to predict respiratory failure.104 In addition, other studies have also shown the remarkably increased serum levels of IL-6 in patients with severe COVID-19.68,105,106. This evidence concerns the gene IL6 and respiratory failure.