Antigen peptide pools stimulated-IL-2 and -IFN-γ positive responses were associated with significantly better survival of NAb, anti-S1 IgG, anti-RBD IgG, and anti-NP-S1 IgG in COVID-19 convalescent individuals, while the antigen peptide pools stimulated-IL-8 positive response was associated with significantly worse antibody survival. This evidence concerns the gene IL2 and COVID-19.