Cases of severe infection requiring antibiotic therapy, including Pneumocystis jirovecii have been reported,18 19 as well as hypersensitivity reactions to infliximab.18 Furthermore, given that TNF has a pleiotropic role in the cancer immunity cycle and was previously proposed as a treatment for melanoma,20 it is important to define the impact of TNF antagonism on cancer outcomes. The gene discussed is TNF; the disease is infection.