These observations suggest that reduced α-KGDH activity alone is sufficient to recapitulate the metabolic deficits observed in AD and is in line with a study by Yao et al. [46] wherein 3-month old 3xTg-AD mice were found to have reduced mitochondrial respiration and PDH activity, coupled with increased ROS generation [46]. The gene discussed is PDP1; the disease is Alzheimer disease.