We then identified nine subgroups of M cells based on their molecular markers (Fig. 7E–G; Additional file 10) and compared the proportion of subclusters among the three groups (Additional file 1: Fig. S7G, H), which showed an increased proportion of CX3CR1 + CCR2 + monocytes/macrophages (SC-M-2) and CXCL5 + IL6 + monocytes/macrophages (SC-M-4) in endometriosis, with a decreased ratio of CXCL12 + monocytes/macrophages (SC-M-1) and CD1 + monocytes/macrophages (SC-M-3). The gene discussed is CCR2; the disease is endometriosis.