For conventional CD4 + T cells, the ratio of naive SC-T-2 decreased in endometriosis (20.61% in endometriosis lesions vs. 28.02% in eutopic endometrium and 32.17% in normal endometrium), with increased effector SC-T-5_1 (7.30% in endometriosis lesions and 2.24% in eutopic endometrium vs 1.40% in normal endometrium) (Additional file 1: Fig. S7A, B, Additional file 8). This evidence concerns the gene CD4 and endometriosis.