The larger transcriptome and proteome differences observed between KRAS and BRAF mutants than between KRAS mutants and cells lacking Ras pathway mutation are in line with previous findings in transcriptomes of 381 human CRCs with BRAF, KRAS or unknown mutation in the EGFR pathway, where the BRAF mutant tumours constituted a separate group [69]. The gene discussed is EGFR; the disease is neoplasm.