The Molecule Activation Prediction (MAP) tool predicted ILK signal activation based on the protein expression changes in KRAS G12D and G13D, which is in turn predicted to activate downstream genes related to cell proliferation, adhesion, motility, cancer progression EMT, cancer stem cell markers and chemoresistance [45, 46] (Supplementary Fig. 7 A-C, Additional File 1). This evidence concerns the gene KRAS and cancer.