Different subtypes of genetic mutations are described as a possible cause of leiomyoma development, including high mobility group AT-hook 2 (HMGA2) rearrangements, mediator complex subunit 12 (MED12) mutations, biallelic inactivation of fumarate hydratase (FH), and deletions affecting collagen type IV alpha 5 and alpha 6 (COL4A5 and COL4A6) [15]. This evidence concerns the gene MED12 and leiomyoma.