In the context that increased LAE ACE2 expression may increase susceptibility to the extent of infection in asthmatics exposed to SARS-CoV-2, although ICS are the cornerstone of asthma therapy, and asthma should be controlled in all patients, management of patients with asthma infected by SARS-CoV-2, including adjustment of medication, should be considered on an individual basis. The gene discussed is ACE2; the disease is infection.