In the reports of breast cancer and colorectal cancer, ELK3 is closely related to chemotherapy resistance, and down-regulating its expression can promote chemotherapy sensitivity [35, 36].In addition, ELK3 is also involved in TGF-β signaling to promote tumor cells to undergo epithelial-mesenchymal transition [37, 38]. This evidence concerns the gene ELK3 and colorectal cancer.