Our data confirmed the achievements of former investigations [10, 17, 18, 23, 24] by several BMI ranges that not only HSD11B1 and HSD11B2 mRNA are present in both subjects but also the expression of HSD11B1 are more in subcutaneous AT of women with PCOS than non-PCOS. The gene discussed is HSD11B2; the disease is polycystic ovary syndrome.