AKT1 and colorectal carcinoma: Zhao et al. found that the overexpression of CXCL5 could induce the epithelial-mesenchymal transition (EMT) to enhance the invasion and migration of CRC cells by the activation of the AKT/GSK3β/β-catenin and the ERK/Elk-1/Snail pathways in a CXCR2-dependent manner [17].