The mRNA levels of CXCL5 in rectosigmoid adenocarcinoma (fold change = 11.693, P = 8.34E-14), colon adenocarcinoma (fold change = 2.739, P = 3.60E-22), colon mucinous adenocarcinoma (fold change = 23.08, P = 9.97E-11), and rectal adenocarcinoma (fold change = 2.538, P = 3.20E-13) were significantly higher in TCGA dataset. This evidence concerns the gene CXCL5 and digestive system cancer.