As shown as Supplementary Figure 1D, we also found significant enrichment in KEGG pathways, including chemokine signaling pathway (Supplementary Figure 2A), cytokine-cytokine receptor interaction (Supplementary Figure 2B), legionellosis, Salmonella infection, toll-like receptor signaling pathway, NOD-like receptor signaling pathway, rheumatoid arthritis, pertussis, and TNF signaling pathway. This evidence concerns the gene TNF and rheumatoid arthritis.