PAK4 and neoplasm: Contrary to the serum profile (Fig 4B), urine from OH-BBN induced C57BL/6 mice displayed increased levels of the pro-inflammatory cytokines Ccl3 and Il1β, as well as an upregulation of tumor promoting Ppp1r2, Pak4, tumor growth marker Nadk, and Dctn2 (Fig 4F).