It is however plausible that tumor resection and combination therapies might be the key to achieve complete tumor regression for progressive disease or that the model could be a useful tool to further study mechanisms of immunotherapy resistance, since a recent study showed that anti-PD1 therapy of OH-BBN induced MIBC tumors in wild type C57BL/6 mice had a therapeutic effect [82]. The gene discussed is PDCD1; the disease is neoplasm.