Contrary to the serum profile (Fig 4B), urine from OH-BBN induced C57BL/6 mice displayed increased levels of the pro-inflammatory cytokines Ccl3 and Il1β, as well as an upregulation of tumor promoting Ppp1r2, Pak4, tumor growth marker Nadk, and Dctn2 (Fig 4F). This evidence concerns the gene NADK and neoplasm.