These results are consistent with our recent studies, in which we demonstrated that MBZ modulated the cancer-associated pathways including ELK1/SRF, AP1, STAT1/2, MYC/MAX, and synergized with cisplatin in suppressing cell proliferation and inducing apoptosis of human HNSCC cells [18]. The gene discussed is MAX; the disease is head and neck squamous cell carcinoma.