NPM1 and acute myeloid leukemia: In multivariate analysis, advanced age, cytogenetic risk, and NPM1 wild type (wt) were independent risk factors for CR and in addition male gender (p < 0.05), abnormal WBC (< 2 / 2–75 / > 75; p < 0.001), and AML type (p < 0.01) for OS (data not shown).