ZEB2 and breast carcinoma: It is reported that lincRNA-ROR regulates the expression of core transcription factors and differentiation-related miRNAs involving in human embryonic stem cell self-renewal.[34] Moreover, lincRNA-ROR induces EMT by regulation the degradation of microRNA-205 target genes ZEB2 in breast cancer.[35] On other hand, lincRNA-ROR mediates multiple signaling pathways involving in the growth and progression of various tumors.