The lack of novel treatment options, coupled with the challenges of long-term insulin therapy, makes it difficult for patients with T1DM to reach and maintain hemoglobin A1c goals, which increases the risk of complications.[1,2] In addition, tolerance to insulin therapy depends on the relationship between the adverse effects of balancing weight gain and hypoglycemia and the achievement of blood glucose goals.[3]. Here, INS is linked to Hypoglycemia.