In this mSphere of Influence article, he reflects on how the paper “Succinate is an inflammatory signal that induces IL-1β through HIF-1α” by Tannahill et al. (G. M. Tannahill, A. M. Curtis, J. Adamik, E. M. Palsson-McDermott, et al., Nature 496:238–242, 2013, https://doi.org/10.1038/nature11986) influenced him by highlighting the intersection between metabolism and the host response to infectious diseases. This evidence concerns the gene IL1B and infectious disease.