IL6 and peripheral arterial disease: IL‐6 also plays a role in regulating the exaggerated BP response to static exercise in PAD rats (Copp et al., 2015) likely via membrane‐bound IL‐6R or gp130 trans‐signaling pathways assembled by soluble form of IL‐6R (Jostock et al., 2001; Scheller et al., 2014; Wolf et al., 2014).