In conclusion, we found increases in the levels of IL‐6 and expression of its receptor IL‐6R in DRGs of PAD rat, which are likely to decrease the activities of Kv4 channels in muscle DRG neurons via IL‐6 trans‐signaling pathways and make IL‐6‐Kv4 channel signaling a specific molecular mechanism leading to the exaggerated pressor reflex in PAD. This evidence concerns the gene IL6 and peripheral arterial disease.