Our study revealed that NEAT1 was downregulated in DCM rats, and the combination of dendrobium and Met altered the levels of Nrf2 and miR-23a-3p by regulating NEAT1 expression levels in myocardial cells from rats with high-glucose (HG) diet-induced DM and in rats with streptozotocin (STZ)-induced DCM. The gene discussed is NFE2L2; the disease is familial dilated cardiomyopathy.