HPRT1 and cancer: Moreover, the prognosis data obtained from the Kaplan–Meier Plotter disclosed that the higher expression levels of the HPRT1 gene in cancer tissues were significantly correlated with inferior survival time of patients with HNSCC, in line with the findings of previous studies that suggested the dysregulation of the HPRT1 expression was associated with poor survival outcomes of breast and endometrial cancers [17, 18].