Among them, IGF2BP2, ENO2, NETO2, HOXA10 and MYBL2 were the top five up‐regulated (Fig. 7C), and SPINK5, SLURP1, HOPX, CRCT1 and CNFN were the top five down‐regulated coexpressed genes of the HPRT1 gene in HNSCC (Fig. 7D). Here, CRCT1 is linked to head and neck squamous cell carcinoma.