Among them, IGF2BP2, ENO2, NETO2, HOXA10 and MYBL2 were the top five up‐regulated (Fig. 7C), and SPINK5, SLURP1, HOPX, CRCT1 and CNFN were the top five down‐regulated coexpressed genes of the HPRT1 gene in HNSCC (Fig. 7D). The gene discussed is ENO2; the disease is head and neck squamous cell carcinoma.