In those animals, resistance to diet‐induced hepatic steatosis seems to be due at least in part to an increased feedback inhibition of insulin signaling at the level of the insulin receptor substrate 1 through S6K1‐dependent and ‐independent mechanisms (Kenerson et al., 2015; Kucejova et al., 2016; Yecies et al., 2011). The gene discussed is INS; the disease is fatty liver disease.