Although not previously evaluated for their effects on mitochondrial morphology, the compounds celastrol and withaferin A have been reported to reduce ER stress, sensitize to leptin, and protect from HFD‐induced obesity (Liu et al, 2015; Lee et al, 2016), outcomes that would be consistent with reduced mitochondrial fission. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.