Although a more in‐depth characterization of SH‐BC‐893’s toxicity profile will be an important next step, unchanged voluntary wheel running (Figs 6L and EV4C–E), observations that adiponectin reduces depressive behaviors in mice (Yau et al, 2014), and reports linking depression to mitochondrial fragmentation in multiple cell types (Fan et al, 2019; Gebara et al, 2020) suggest that SH‐BC‐893 may not only avoid the negative psychiatric side effects of previous appetite suppressants (Sam et al, 2011), but actually prove beneficial. This evidence concerns the gene ADIPOQ and major depressive disorder.