Mdivi‐1 reduces ROS production in palmitate‐ or ceramide‐treated C2C12 myotubes (Smith et al, 2013), moderately improves insulin resistance without affecting glucose clearance in ob/ob mice (Jheng et al, 2012), restores insulin‐mediated suppression of hepatic glucose production in HFD‐fed rats (Filippi et al, 2017), and slows the progression of diabetic nephropathy in db/db mice (Ayanga et al, 2016). Here, INS is linked to Insulin resistance.