Agents reported to target the mitochondrial fission factor DRP1 or to up‐regulate the fusion factor MFN2 have been evaluated in obesity models (Jheng et al, 2012; Ayanga et al, 2016; Filippi et al, 2017; Chen et al, 2018). Here, MFN2 is linked to obesity due to melanocortin 4 receptor deficiency.