FLT3 and acute myeloid leukemia: However, FLT3-ITD mutations in AML with a t(8;21) translocation, detected in one of our patients, is thought to be uncommon, occurring in less than 10% of AML cases.21 The reported frequency of FLT3-ITD mutations in CN-AML in African populations varies significantly from 11% in South African patients to up to 34.6% in an Egyptian cohort, which is more in line with data from high-income countries.9,15,22 The absence of FLT3-ITD in CN-AML patients in our study was unexpected, but could likely be attributed to the small study cohort.