Whilst previous analysis of genetic/epigenetic changes would not have readily identified the genes identified here, some could have been identified solely through subtype-specific overexpression (as was the case for IGF2BP1 [16, 17] and WNT16 [18] in ALL and ATOH1 [24] in medulloblastoma). This evidence concerns the gene ATOH1 and acute lymphoblastic leukemia.